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Lack of Syndecan-1 Enhances Interaction Between Leukocytes and Endothelial Cells 1Peters S., 1Radetzky S., 2Götte M., 3Bernfield M., 1Joussen A. M.,
Purpose: Leukocyte-endothelial interactions play an important role in angiogenesis as well as in vascular diseases as non-proliferative diabetic retinopathy or uveitis. Leukocyte adhesion to the endothelium and following extravasation during inflammation is mediated by cell surface molecules like selectins, cell adhesion molecules, integrins and chemokines. The present study investigates the influence of Syndecan-1 a heparan sulfate proteoglycan binding and modyfying these cell surface molecules on the leukocyte-endothelial interaction. |
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