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Programm & Abstracts "Innovationen in der Augenheilkunde" | |
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Mycophenolate Mofetil - a New Anti-scarring Agent in Glaucoma Surgery? 1Heinz C., 2Hudde T., 2Heise K., 3Steuhl K. P.,
Purpose: In penetrating glaucoma surgery antiproliferatives like mitomycin C and 5-fluorouracil are used to prevent scarring of the filtering bleb. Exaggerated scarring or severe complications might occur. We previously demonstrated, that mycophenolate mofetil (MMF), an immunosuppressive agent in organ transplantation, inhibits human Tenon fibroblasts (HTF) in vitro. MMF blocks the inosinmonophosphate dehydrogenase of the guanosine de novo synthesis. In many cell types a salvage pathway for guanosine exists. In this work we investigated if guanosine antagonises the MMF effect on HTF and evaluated HTF migration in a model. |
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