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Oxidative Stress Induces Synthesis of TGF-beta2 and Increases ECM Gene-expression in Retinal Pigment Epithelial Cells Alge C., Priglinger S., Neubauer A. S., Kampik A., Welge-Lüßen U.,
Purpose: Age related macular degeneration (AMD) is the leading cause of severe vision loss in the western world. Early AMD is characterized in part by the deposition of extracellular matrix (ECM) material between the retinal pigment epithelium (RPE) and the choroid. Oxidative stress and an increased expression of the fibrogenic cytokine transforming growth factor beta 2 (TGF-beta2) have been discussed to contribute to AMD pathogenesis. The present study was designed to explore the causal relationship between oxidative stress and the expression of TGF-beta2 and ECM proteins in the RPE. |
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