Programm & Abstracts                 "Innovationen in der Augenheilkunde"

Aktuelle Tagungsinformationen
   News and Updates

Anmeldung zur Tagung
   Hotel Registration
   Welcome address
Beteiligte Gesellschaften
   Societies involved
Eröffnung des Kongresses
   Opening Ceremony
Wissenschaftliches Programm
   Scientific program
   Poster Presentation
Begleitende Veranstaltungen
   Collateral Events
   Social program
   Jubilee Party
DOG Information
   DOG Information
Allgemeine Informationen
   General Information
   Index of Authors
   Registration fees

DOG Homepage

Ocular Manifestations of Graft versus Host Disease Following Bone-marrow Transplantation

1Haka B., 2Müller-Molaian I., 1Palmowski A., 2Püschel W., 1Ruprecht K. W.,
1Universitätskliniken des Saarlandes, Augenklinik und Poliklinik (Homburg/Saar)
2Universitätskliniken des Saarlandes, Institut für Pathologie (Homburg/Saar)

Graft versus Host Disease (GvHD) is a common complication after bone marrow transplantation. Ocular symptoms often consist of chronic keratoconjunctivitis and another complication in all compartments of eye.
Case report: Over a period of 3 months 4 GvHD patients presented with chronic keratoconjunctivitis and subtarsal scarring. One patient showed a minor keratitis. Three patients were in a poor state of general health and showed hyperpigmentation and atrophy of the skin. All patients developed conjunctival chemosis. In one patient the kerathopathy consisted of epithelial defects as well as a stromal infiltrate. Another patient developed a corneal melting syndrome with a marked keratitis on histopathology. The third presented a corneal graft rejection associated with an epithelial defect. The histology showed pathological corneal epithelium, inflammatory cells, focal loss of bowman’s membrane and endothelium, associated with a corneal graft rejection.
Therapy: The local therapy for minor keratitis consisted of tear substitution and punctum plugs. Corneal infiltrates profited from local Ciclosporin A therapy. The corneal defects in the patients with the graft rejection improved by using a therapeutic contact-lens. A keratoplasty a chaud was performed in the eye with corneal melting syndrome.
Conclusions: Usually severe ocular complications are associated with severe systemic GvHD and result in a higher patient mortality. Interdisciplinary cooperation between ophthalmologists, internists and pathologists is highly recommended.