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Effect of Intravitreal Crystalline Triamcinolone Acetonide on Retinal Neovascularization in a Mouse Model with Premature Retinopathy
Spandau U.,
Ruprecht-Karls-Universität Heidelberg, Fakultät für klinische Medizin Mannheim, Augenklinik (Mannheim)
Purpose: Intravitreal crystalline triamcinolone acetonide seems to have a positive clinical effect on proliferative and edematous retinal diseases. Purpose of this study was to investigate the angiostatic effect of crystalline triamcinolone acetonide on neovascularization in a retinopathy of prematurity (ROP) mouse model.
Methods: Mice were incubated from P7-P12 with 75% O2. On P12, 1 microl of crystalline triamcinolone acetonide was injected once into the vitreous. 1 microl saline was injected in the second eye as a control. On P17, mice were sacrificed and eyes were analyzed. Retinal neovascularization was assessed by counting vascular cell nuclei on the vitreal side of the internal limiting membrane.
Results: Relative hypoxia resulted in retinal and intravitreal proliferation of blood vessels. After intravitreal injection of crystalline triamcinolone acetonide, pathologic proliferation of retinal blood vessels was reduced by 56% (mean=15.45 ± 1.62 neovascular nuclei per section) compared to control eyes (Mean=8.6 ± 1.48; P<0.005).
Conclusions: Intravitreal crystalline triamcinolone acetonide may have an angiostatic effect in mice eyes with a model of retinopathy of prematurity.