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Multifocal Electroretinography: Comparison of Repeatability between Monitor- and LED-Stimulation

Mazinani B. A. E., Amjadi A., Weinberger A. W. A., Schrage N. F.,
RWTH Aachen, Universitätsaugenklinik (Aachen)

Purpose: LED-stimulation with cyclic summation in MF-ERG provides a similar topographical analysis of retinal function compared to monitor-stimulation with significantly lower examination times. Purpose of this study is to show wether the new examination method has also a comparable repeatability to conventional stimulation.
Method: Seven healthy subjects were examined at two appointments at an interval of at least 3 weeks by monitor- and LED-stimulation with a resolution of 61 areas (RETIscan, Roland Consult, Wiesbaden). In LED stimulation with cyclic summation, each array of the stimulation pattern is triggered with a slightly different amplitude of about 30 Hz. After the recording, the curves of the single areas can be traced back according to the principles of a Fourier analysis. An examination of an area of 30° with a resolution of 61 hexagons takes about 32 sec. An examination using monitor-stimulation and M-sequences takes at least 4 min with the same resolution.
Results: Repeatability was calculated using coefficients of variation. Both methods came to coefficients of under 10% for the latency of the b-wave and under 20% for the amplitude of the b-wave with a slightly better intraindividual stability of the latencies in LED-stimulation, whereas the monitor stimulation showed slightly lower coefficients of the amplitudes.
Conclusions: The significantly shorter examination time in cyclic summation leads to a considerable relief for the patient and the examiner. This study shows that these shorter examination times are not accompanied by a loss of intraindividual examination stability.