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Electrophysiological findings after Intravitreal Injection of Triamcinolone Acetonide

Degenring R. F., Schulte J., Jonas J. B.,
Ruprecht-Karls-Universität Heidelberg, Fakultät für klinische Medizin Mannheim, Augenklinik (Mannheim)

Purpose: To evaluate whether electrophysiological changes can be found after an intravitreal injection of 25 mg Triamcinolone Acetonide.
Method: The study included 11 patients who had received an intravitreal injection of 25 mg triamcinolone acetonide for various reasons and who underwent standard-electrooculography (EOG) (n=10) and electroretinography (ERG) (n=11) (scotopic intensities 2500 mcds/m2, 40 mcds/m2, 4 mcds/m2 and 0,4 mcds/m2; photopic intensities 15 cds/m2, 8 cds/m2 and 4 cds/m2 and Flicker-ERG with 2,5 cds/m2). Comparing the treated eye with the contralateral untreated eye in an intra-individual bilateral comparison, we assessed the amplitude and latency of a-wave, difference in the amplitude of the a-/b-wave and the latency of the b-wave for photopic and scotopic ERG, and the difference in the amplitude of b1-b2-wave for the Flicker-ERG. For the EOG minimal and maximal amplitudes were obtained. Mean time interval between the intravitreal injection and the electrographical testing was 24.8 ± 13.5 weeks with a minimum of 6 weeks.
Results: In photopic, scotopic and Flicker-ERG, no statistically significant changes were found between the treated eyes and the untreated eyes for all intensities. In the EOG, the minimal and maximal amplitudes were higher, however not significantly higher (p=0.114 resp. P=0.139) in the treated eye than in the control eye.
Conclusions: This electrophysiological study did not reveal any negative influence of an intravitreal injection of 25 mg triamcinolone acetonide on the function of the retina or the retinal pigment epithelium over the follow-up time of this study.