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European Glaucoma Prevention Study (EGPS)

Vogel A.,
Johannes-Gutenberg-Universität Mainz, Universitäts-Augenklinik (Mainz)

Purpose: To evaluate the efficacy of reduction of intraocular pressure (IOP), by means of dorzolamide, in preventing patients affected by ocular hypertension from developing glaucoma.
Design: Randomized, placebo controlled, double blind, clinical multicenter trial in 18 centers of 4 European countries (Germany, Italy, Belgium, Portugal).
Patients and methods: 1075 patients with ocular hypertension were randomized to either treatment with dorzolamide or placebo. Clinical examinations are performed every 6 months, including visual acuity, IOP, visual fields, stereoscopic optic disc photographies, HRT). There are two primary endpoints, optic disc progression and visual field progression, and one safety endpoint, IOP > 35 mmHg.
Study status: Randomization: 1/1997 - 5/1999. End of stuy after finishing 5 years of follow-up per patient or after having reached 101 endpoints.

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