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Reduced Blood-flow and Increased Endothelin-1 Plasma Lvels in Patients with Optic Neuritis Pache M., Kaiser H. J., Haufschild T., Flammer J.,
Purpose: Increased endothelin-1 (ET-1) plasma levels have been found in various autoimmune diseases including multiple sclerosis (MS). ET-1 is a potent vasoconstrictor, which might also function as a pro-inflammatory mediator. Given the fact that ET-1 is a potent vasoconstrictor in ocular vessels, we hypothesized that ocular and peripheral blood flow might be reduced in patients with optic neuritis. Therefore, we evaluated ET-1 plasma levels in these patients and measured peripheral and extraocular blood flow velocity in parallel. |
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